Adrenomedullin as a potential biomarker involved in patients with hereditary hemorrhagic telangiectasia

BackgroundAdrenomedullin (AM) is a vasoactive peptide mostly secreted by endothelial cells with an important role in preserving integrity. The relationship between AM and hereditary hemorrhagic telangiectasia (HHT) unknown. We aimed to compare the serum levels tissue expression of HHT patients controls.MethodsSerum were measured radioimmunoassay compared control groups. also among subgroups according clinical characteristics. single nucleotide polymorphism (SNP) rs4910118 was assessed restriction analysis sequencing. immunohistochemistry performed on biopsies cutaneous from eight healthy skin five group.ResultsForty-five 50 controls included, mean age (SD) 50.7 (14.9) years 46.4 (9.9) (p = 0.102), respectively. female (60% vs 38%, p 0.032). Median [Q1-Q3] 68.3 [58.1–80.6] pg/mL group 47.7 [43.2–53.8] (p<0.001), optimal cut-off Youden's J statistic 55.32 (J:0.729). Serum similar subgroups. No patient had SNP rs4910118. immunoreactivity found high intensity abnormal blood vessels biopsies.ConclusionsWe detected higher than controls. HHT, whether may constitute novel biomarker therapeutic target, needs further investigation.